Fitxers

630226.pdf (1.28 MB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2014-07-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/157017

Vestibular damage in chronic ototoxicity: a mini-review

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.neuro.2013.11.009

Resum

Ototoxicity is a major cause of the loss of hearing and balance in humans. Ototoxic compounds include pharmaceuticals such as aminoglycoside antibiotics, anti-malarial drugs, loop diuretics and chemotherapeutic platinum agents, and industrial chemicals including several solvents and nitriles. Human and rodent data indicate that the main target of toxicity is hair cells (HCs), which are the mechanosensory cells responsible for sensory transduction in both the auditory and the vestibular system. Nevertheless, the compounds may also affect the auditory and vestibular ganglion neurons. Exposure to ototoxic compounds has been found to cause HC apoptosis, HC necrosis, and damage to the afferent terminals, of differing severity depending on the ototoxicity model. One major pathway frequently involved in HC apoptosis is the c-jun N-terminal kinase (JNK) signaling pathway activated by reactive oxygen species, but other apoptotic pathways can also play a role in ototoxicity. Moreover, little is known about the effects of chronic low-dose exposure. In rodent vestibular epithelia, extrusion of live HCs from the sensory epithelium may be the predominant form of cell demise during chronic ototoxicity. In addition, greater involvement of the afferent terminals may occur, particularly the calyx units contacting type I vestibular HCs. As glutamate is the neurotransmitter in this synapse, excitotoxic phenomena may participate in afferent and ganglion neuron damage. Better knowledge of the events that take place in chronic ototoxicity is of great interest, as it will increase understanding of the sensory loss associated with chronic exposure and ageing.

Matèries

Agents antiinfecciosos, Cèl·lules acústiques, Patologia, Malalties neurodegeneratives, Ressenyes sistemàtiques (Investigació mèdica)

Matèries (anglès)

Anti-infective agents, Hair cells, Pathology, Neurodegenerative Diseases, Systematic reviews (Medical research)

Citació

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SEDÓ CABEZÓN, Lara, et al. Vestibular damage in chronic ototoxicity: a mini-review. Neurotoxicology. 2014. Vol. 43, num. 21-27. ISSN 0161-813X. [consulted: 25 of May of 2026]. Available at: https://hdl.handle.net/2445/157017

Exportar metadades

JSON - METS

Compartir registre