A General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines

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dc.contributor.authorAmat Tusón, Mercedes
dc.contributor.authorFabregat, Robert
dc.contributor.authorGriera Farres, Rosa
dc.contributor.authorBosch Cartes, Joan
dc.date.accessioned2017-03-10T15:24:51Z
dc.date.available2017-03-10T15:24:51Z
dc.date.issued2009-02-20
dc.date.updated2017-03-10T15:24:51Z
dc.description.abstractA practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec566015
dc.identifier.issn0022-3263
dc.identifier.urihttps://hdl.handle.net/2445/108263
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/jo802587h.
dc.relation.ispartofJournal of Organic Chemistry, 2009, vol. 74, num. 4, p. 1794-1797
dc.relation.urihttps://doi.org/10.1021/jo802587h.
dc.rights(c) American Chemical Society , 2009
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationQuinolones
dc.subject.classificationSíntesi orgànica
dc.subject.classificationLactames
dc.subject.classificationReacció d'oxidació-reducció
dc.subject.otherQuinolone antibacterial agents
dc.subject.otherOrganic synthesis
dc.subject.otherLactams
dc.subject.otherOxidation-reduction reaction
dc.titleA General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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