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Document embargat fins el 2026-11-26

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2026-05-27

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230072

Glycogen drives the sensory activation of POMC neurons

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Recurs relacionat

https://doi.org/10.1038/s42255-026-01535-7

Resum

Hypothalamic POMC neurons modulate systemic energy balance and glucose homeostasis by sensing nutritional state signals. In addition to this classic regulatory mode, these neurons are also activated by the sensory perception of food. Here, we report that food-related sensory cues engage glycogen metabolism in POMC neurons. Genetic depletion of glycogen through various approaches renders POMC neurons unresponsive to food-associated sensory stimuli. This defective perception of food is linked to alterations in consummatory behaviour, hepatic adaptations and cephalic insulin release associated with a prediabetic phenotype that progresses into overweight and overt diabetes with a high-calorie diet or ageing. Collectively, our results posit glycogen as a decisive fuel resource for meeting the rapid and demanding energy requirements linked with sensory activation. Furthermore, our data delineate the biological function of food perception and provide support for the physiological relevance of neuronal glycogen.

Matèries

Diabetis, Neuroquímica, Neurones sensorials

Matèries (anglès)

Diabetes, Neurochemistry, Sensory neurons

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

GÓMEZ-VALADÉS, Alicia G., et al. Glycogen drives the sensory activation of POMC neurons. Nature Metabolism. 2026. ISSN 2522-5812. [consulted: 1 of July of 2026]. Available at: https://hdl.handle.net/2445/230072

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