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2011-08-16

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/54982

Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine

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http://dx.doi.org/10.1016/j.tetlet.2011.07.128

Abstract

(S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions.

Subject

Productes naturals, Antibiòtics, Síntesi de pèptids, Compostos heterocíclics, Enantiòmers

Subject (English)

Natural products, Antibiotics, Peptide synthesis, Heterocyclic compounds, Enantiomers

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

JUST BARINGO, Xavier, et al. Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine. Tetrahedron Letters. 2011. Vol. 52, num. 42, pags. 5435-5437. ISSN 0040-4039. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/54982

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