Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine

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dc.contributor.authorJust Baringo, Xavier
dc.contributor.authorBruno, Paolo
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorÁlvarez Domingo, Mercedes
dc.date.accessioned2014-06-13T10:51:08Z
dc.date.available2014-06-13T10:51:08Z
dc.date.issued2011-08-16
dc.date.updated2014-06-13T10:51:08Z
dc.description.abstract(S)-2-(4-Bromo-2,4"-bithiazole)-1-(tert-butoxycarbonyl)pyrrolidine ((S)-1) was obtained as a single enantiomer and in high yield by means of a two-step modified Hantzsch thiazole synthesis reaction when bromoketone 3 and thioamide (S)-4 were used. Further conversion of (S)-1 into trimethyltin derivative (S)-2 broadens the scope for further cross-coupling reactions.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec598512
dc.identifier.issn0040-4039
dc.identifier.urihttps://hdl.handle.net/2445/54982
dc.language.isoeng
dc.publisherElsevier Ltd
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.tetlet.2011.07.128
dc.relation.ispartofTetrahedron Letters, 2011, vol. 52, num. 42, p. 5435-5437
dc.relation.urihttp://dx.doi.org/10.1016/j.tetlet.2011.07.128
dc.rights(c) Elsevier Ltd, 2011
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationProductes naturals
dc.subject.classificationAntibiòtics
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationCompostos heterocíclics
dc.subject.classificationEnantiòmers
dc.subject.otherNatural products
dc.subject.otherAntibiotics
dc.subject.otherPeptide synthesis
dc.subject.otherHeterocyclic compounds
dc.subject.otherEnantiomers
dc.titleHighly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)