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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/101981
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
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The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the redn. of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: in most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and Et acetate, with no loss of selectivity.
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SALOMÓ I PRAT, Ernest, et al. Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides. Angewandte Chemie International Edition. 2016. Vol. 55, num. 7988-7992. ISSN 0003-3022. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/101981