Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

Lineage origin and transcriptional control of autoantigen.pdf (2.38 MB)

Document type

Article

Version

Published version

Publication date

2023-09-25

Publication license

cc by (c) Angelats Canals, Edgar et al, 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/214354

Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.3389/fimmu.2023.1267697

Abstract

T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.

Subject

Cèl·lules T, Nanomedicina

Subject (English)

T cells, Nanomedicine

Citation

Collections

Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

ANGELATS CANALS, Edgar and SANTAMARIA VILANOVA, Pere. Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells. Frontiers In Immunology. 2023. Vol. 14. ISSN 1664-3224. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/214354

Export metadata

JSON - METS

Share record