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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175838
Light-dependent translocation of arrestin in the absence of rhodopsin phophorylation and transducin signaling
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Visual arrestin plays a crucial role in the termination of the light response in vertebrate photoreceptors by binding selectively to light-activated, phosphorylated rhodopsin. Arrestin localizes predominantly to the inner segments and perinuclear region of dark-adapted rod photoreceptors, whereas light induces redistribution of arrestin to the rod outer segments. The mechanism by which arrestin redistributes in response to light is not known, but it is thought to be associated with the ability of arrestin to bind photolyzed, phosphorylated rhodopsin in the outer segment. In this study, we show that light-driven translocation of arrestin is unaffected in two different mouse models in which rhodopsin phosphorylation is lacking. We further show that arrestin movement is initiated by rhodopsin but does not require transducin signaling. These results exclude passive diffusion and point toward active transport as the mechanism for light-dependent arrestin movement in rod photoreceptor cells.
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MÉNDEZ ZUNZUNEGUI, Ana, LEM, Janis, SIMON, Melvin i., CHEN, Jeannie. Light-dependent translocation of arrestin in the absence of rhodopsin phophorylation and transducin signaling. _Journal of Neuroscience_. 2003. Vol. 23, núm. 8, pàgs. 3124-3129. [consulta: 18 de febrer de 2026]. ISSN: 0270-6474. [Disponible a: https://hdl.handle.net/2445/175838]