Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

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dc.contributor.authorJi, Xuemei
dc.contributor.authorBossé, Yohan
dc.contributor.authorLandi, Maria Teresa
dc.contributor.authorGui, Jiang
dc.contributor.authorXiao, Xiangjun
dc.contributor.authorQian, David
dc.contributor.authorJoubert, Philippe
dc.contributor.authorLamontagne, Maxime
dc.contributor.authorLi, Yafang
dc.contributor.authorGorlov, Ivan
dc.contributor.authorBiasi, Mariella de
dc.contributor.authorJanout, Vladimir
dc.contributor.authorKontic, Milica
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorSwiatkowska, Beata
dc.contributor.authorJohansson, M
dc.contributor.authorZaridze, David
dc.contributor.authorBakke, Per
dc.contributor.authorSkaug, Vidar
dc.contributor.authorZienolddiny, Shanbeh
dc.contributor.authorJohansson, Mattias
dc.contributor.authorButler, Lesley M.
dc.contributor.authorByun, Jinyoung
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorObeidat, Ma'en
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorHoulston, Richard
dc.contributor.authorMcLaughlin, John R.
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorTimens, Wim
dc.contributor.authorHung, Rayjean J.
dc.contributor.authorSong, Lei
dc.contributor.authorZhu, Bin
dc.contributor.authorGu, Fangyi
dc.contributor.authorSoler Artigas, María
dc.contributor.authorTobin, Martin D.
dc.contributor.authorWain, Louise V.
dc.contributor.authorKamal, Ahsan
dc.contributor.authorZhu, Dakai
dc.contributor.authorTardón, Adonina
dc.contributor.authorTyndale, Rachel F.
dc.contributor.authorWei, Wei-Qi
dc.contributor.authorMarchand, Loïc Le
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorBrennan, Paul
dc.contributor.authorWu, Xifeng
dc.contributor.authorChen, Chu
dc.contributor.authorMcKay, James D.
dc.contributor.authorLiu, Geoffrey
dc.contributor.authorZong, Xuchen
dc.contributor.authorCarreras-Torres, Robert
dc.contributor.authorChristiani, David C.
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorRennert, Gad
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorSchabath, Matthew B.
dc.contributor.authorYe, Yuanqing
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorBickeböller, Heike
dc.contributor.authorAldrich, Melinda C.
dc.contributor.authorBush, William S.
dc.contributor.authorTeare, M. Dawn
dc.contributor.authorField, John K.
dc.contributor.authorSaliba, Walid
dc.contributor.authorSu, Li
dc.contributor.authorKiemeney, Lambertus A. L. M.
dc.contributor.authorPhilip, Lazarus
dc.contributor.authorHaugen, Aage
dc.contributor.authorLam, Stephen
dc.contributor.authorAndrew, Angeline S.
dc.contributor.authorWilkens, Lynne
dc.contributor.authorShen, Hongbing
dc.contributor.authorDiao, Nancy
dc.contributor.authorHong, Yun-Chul
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorDavies, Michael P. A.
dc.contributor.authorBertazzi, Pier Alberto
dc.contributor.authorPesatori, Angela Cecilia
dc.contributor.authorZhang, Ruyang
dc.contributor.authorHaiman, Christopher
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBrhane, Yonathan
dc.contributor.authorLeighl, Natasha
dc.contributor.authorJohansen, Jakob S.
dc.contributor.authorMellemgaard, Anders
dc.contributor.authorFernández Somoano, Ana
dc.contributor.authorDoherty, Jennifer A.
dc.contributor.authorFernández Tardón, Guillermo
dc.contributor.authorvan der Heijden, Erik H. F. M.
dc.contributor.authorKim, Jin Hee
dc.contributor.authorDai, Juncheng
dc.contributor.authorHu, Zhibin
dc.contributor.authorMarcus, Michael W.
dc.contributor.authorManz, Judith
dc.contributor.authorBrunnström, Hans
dc.contributor.authorTumino, Rosario
dc.contributor.authorManjer, Jonas
dc.contributor.authorTsao, Ming-Sound
dc.contributor.authorMelander, Olle
dc.contributor.authorMuller, David C.
dc.contributor.authorOvervad, Kim
dc.contributor.authorGoodman, Gary E.
dc.contributor.authorMukeriya, Anush
dc.contributor.authorCox, Angela
dc.contributor.authorTaylor, Fiona
dc.contributor.authorWoll, Penella
dc.contributor.authorBrüske, Irene
dc.contributor.authorMuley, Thomas R.
dc.contributor.authorOrlowski, Tadeusz M.
dc.contributor.authorRisch, Angela
dc.contributor.authorArnold, Susanne M.
dc.contributor.authorRosenberger, Albert
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorJohansson, Mikael
dc.contributor.authorShepherd, Frances A.
dc.contributor.authorHaura, Eric B.
dc.contributor.authorDuell, Eric J.
dc.contributor.authorBolca, Ciprian
dc.contributor.authorOgnjanovic, Simona
dc.contributor.authorNickle, David C.
dc.contributor.authorHolcatova, Ivana
dc.date.accessioned2020-11-20T11:38:41Z
dc.date.available2020-11-20T11:38:41Z
dc.date.issued2018-08-13
dc.date.updated2020-11-11T17:42:54Z
dc.description.abstractGenome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid30104567
dc.identifier.urihttps://hdl.handle.net/2445/172224
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41467-018-05074-y
dc.relation.ispartofNature Communications, 2018, vol. 9
dc.relation.urihttps://doi.org/10.1038/s41467-018-05074-y
dc.rightscc by (c) Ji et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationCàncer de pulmó
dc.subject.classificationFactors de risc en les malalties
dc.subject.otherLung cancer
dc.subject.otherRisk factors in diseases
dc.titleIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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