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cc by (c) Boel, Judith A et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225369

Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia

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Background: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown. Methods: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD. Results: PD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C-statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II. Conclusion: MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI.

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BOEL, Judith a, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease, DE BIE, Rob m a, SCHMAND, Ben a, DALRYMPLE-ALFORD, John c, MARRAS, Connie, ADLER, Charles h, GOLDMAN, Jennifer g, TRÖSTER, Alexander i, BURN, David j, LITVAN, Irene, GEURTSEN, Gert j. Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia. _Movement Disorders_. 2022. Vol. 9, núm. 4, pàgs. 479-483. [consulta: 24 de gener de 2026]. ISSN: 0885-3185. [Disponible a: https://hdl.handle.net/2445/225369]

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