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2023-02-11

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cc-by (c) Painous Martí, Cèlia et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220580

Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study.

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Recurs relacionat

https://doi.org/10.1007/s00330-023-09435-0

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Objectives: To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association with clinical and cerebrospinal fluid (CSF) correlates. Methodology: We collected demographic and clinical variables, performed planimetric and shape MRI analyses, and determined CSF neurofilament-light chain (NfL) levels in 84 participants: 11 CS, 12 with Parkinson's disease (PD), 26 with multiple system atrophy (MSA), 21 with progressive supranuclear palsy (PSP), and 14 with corticobasal degeneration (CBD). Results: MSA featured the most extensive and significant brainstem shape narrowing (that is, atrophy), mostly in the pons. CBD presented local atrophy in several small areas in the pons and midbrain compared to PD and CS. PSP presented local atrophy in small areas in the posterior and upper midbrain as well as the rostral pons compared to MSA. Our findings of planimetric MRI measurements and CSF NfL levels replicated those from previous literature. Brainstem shape atrophy correlated with worse motor state in all parkinsonisms and with higher NfL levels in MSA, PSP, and PD. Conclusion: Atypical parkinsonisms present different brainstem shape patterns which correlate with clinical severity and neuronal degeneration. In MSA, shape analysis could be further explored as a potential diagnostic biomarker. By contrast, shape analysis appears to have a rather limited discriminant value in PSP. Key points: • Atypical parkinsonisms present different brainstem shape patterns. • Shape patterns correlate with clinical severity and neuronal degeneration. • In MSA, shape analysis could be further explored as a potential diagnostic biomarker.

Matèries

Ressonància magnètica, Degeneració (Patologia), Malaltia de Parkinson, Tronc de l'encèfal, Forma

Matèries (anglès)

Magnetic resonance, Degeneration (Pathology), Parkinson's disease, Brain stem, Shape

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PAINOUS MARTÍ, Cèlia, PASCUAL-DIAZ, Saül, MUÑOZ-MORENO, Emma, SÁNCHEZ, V., PARIENTE, Jose carlos, PRATS GALINO, Alberto, SOTO GIMENO, Marta, FERNÁNDEZ, Manel, PÉREZ SORIANO, Alexandra, CÁMARA, Ana, MUÑOZ, Esteban, VALLDEORIOLA SERRA, Francesc, CABALLOL, Núria, PONT SUNYER, Claustre, MARTÍN FLORES, Núria, BASORA MACAYA, Misericordia, TIÓ, Montserrat, RÍOS, José, MARTÍ DOMÈNECH, Ma. josep, BARGALLÓ ALABART, Núria​, COMPTA, Yaroslau. Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study.. _European Radiology_. 2023. Vol. 33, núm. 7, pàgs. 4540-4551. [consulta: 27 de gener de 2026]. ISSN: 0938-7994. [Disponible a: https://hdl.handle.net/2445/220580]

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