Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124233
Repertoire Of Balb/c Mice Natural Anti-carbohydrate Antibodies: Mice Vs. Humans Difference, And Otherness Of Individual Animals
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
One of the most common genetic backgrounds for mice used as a model to investigate human diseases is the inbred BALB/c strain. This work is aimed to characterize the pattern of natural anti-carbohydrate antibodies present in the serum of 20 BALB/c mice by printed glycan array technology and to compare their binding specificities with that of human natural anti-carbohydrate antibodies. Natural antibodies (NAbs) from the serum of BALB/c mice interacted with 71 glycans from a library of 419 different carbohydrate structures. However, only seven of these glycans were recognized by the serum of all the animals studied, and other five glycans by at least 80% of mice. The pattern of the 12 glycans mostly recognized by the circulating antibodies of BALB/c mice differed significantly from that observed with natural anti-carbohydrate antibodies in humans. This lack of identical repertoires of natural anti-carbohydrate antibodies between individual inbred mice, and between mice and humans, should be taken into consideration when mouse models are intended to be used for investigation of NAbs in biomedical research.
Matèries (anglès)
Citació
Citació
BELLO GIL, Daniel, KHASBIULLINA, Naylia, SHILOVA, Nadezhda, BOVIN, Nicolai, MÁÑEZ MENDILUCE, Rafael. Repertoire Of Balb/c Mice Natural Anti-carbohydrate Antibodies: Mice Vs. Humans Difference, And Otherness Of Individual Animals. _Frontiers in Immunology_. 2017. Vol. 8. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/124233]