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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175967
Isolation, absolute configuration and cytotoxic activities of alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)
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The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. Keywords: narciclasine; galasine; cytotoxic activity; absolute configuration; vibrational circular dichroism
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LIANZA, Mariacaterina, VERDAN, Maria helena, ANDRADE, Jean paulo de, POLI, Ferruccio, ALMEIDA, Larissa c. de, COSTA-LOTUFO, Leticia v., CUNHA NETO, Álvaro, OLIVEIRA, Sarah c. c., BASTIDA ARMENGOL, Jaume, BATISTA, Andrea n. l., BATISTA JR, João m., BORGES, Warley s.. Isolation, absolute configuration and cytotoxic activities of alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae). _Journal of the Brazilian Chemical Society_. 2020. Vol. 31, núm. 2135-2145. [consulta: 25 de febrer de 2026]. ISSN: 0103-5053. [Disponible a: https://hdl.handle.net/2445/175967]