Isolation, absolute configuration and cytotoxic activities of alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

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dc.contributor.authorLianza, Mariacaterina
dc.contributor.authorVerdan, Maria Helena
dc.contributor.authorAndrade, Jean Paulo de
dc.contributor.authorPoli, Ferruccio
dc.contributor.authorAlmeida, Larissa C. de
dc.contributor.authorCosta-Lotufo, Leticia V.
dc.contributor.authorCunha Neto, Álvaro
dc.contributor.authorOliveira, Sarah C. C.
dc.contributor.authorBastida Armengol, Jaume
dc.contributor.authorBatista, Andrea N. L.
dc.contributor.authorBatista Jr, João M.
dc.contributor.authorBorges, Warley S.
dc.date.accessioned2021-04-01T11:33:42Z
dc.date.available2021-04-01T11:33:42Z
dc.date.issued2020-06-01
dc.date.updated2021-04-01T11:33:42Z
dc.description.abstractThe phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. Keywords: narciclasine; galasine; cytotoxic activity; absolute configuration; vibrational circular dichroism
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec710167
dc.identifier.issn0103-5053
dc.identifier.urihttps://hdl.handle.net/2445/175967
dc.language.isoeng
dc.publisherSociedade Brasileira de Química
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.21577/0103-5053.20200116
dc.relation.ispartofJournal of the Brazilian Chemical Society, 2020, vol. 31, p. 2135-2145
dc.relation.urihttps://doi.org/10.21577/0103-5053.20200116
dc.rightscc-by (c) Sociedade Brasileira de Química, 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Biologia, Sanitat i Medi Ambient)
dc.subject.classificationAlcaloides
dc.subject.classificationCitotoxicitat per mediació cel·lular
dc.subject.classificationDicroisme circular
dc.subject.classificationTumors
dc.subject.otherAlkaloids
dc.subject.otherCell-mediated cytotoxicity
dc.subject.otherCircular dichroism
dc.subject.otherTumors
dc.titleIsolation, absolute configuration and cytotoxic activities of alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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