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2008

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cc-by (c) Roca Cusachs, Alex et al., 2008
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/150971

Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release

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https://doi.org/10.1111/j.1527-3466.2008.00046.x

Resum

The efficacy of a new torasemide prolonged release (PR) formulation to torasemide immediate release (IR) was compared in a randomized noninferiority double‐blind trial. Patients with newly diagnosed mild‐to‐moderate hypertension or unresponsive or poor tolerability to previous antihypertensive monotherapy received 5 mg/day of torasemide‐PR (n = 219) or torasemide‐IR (n = 223) for 12 weeks (uptitration to 10 mg/day if no response at 4 or 8 weeks). Mean diastolic blood pressure (DBP) reduction in the torasemide‐PR group (11.6 ± 7.1 mmHg, 95% confidence interval [CI] 10.6-12.5) versus torasemide‐IR (11.3 ± 7.5 mmHg, 95% CI 10.2-12.3) met the noninferiority criterion of a nonsided 97.5% CI lower than the preestablished margin of 2 mmHg. A significantly higher percentage of patients in the torasemide‐PR group achieved adequate BP control after 8 and 12 weeks. Ambulatory 24‐h BP monitoring (ABPM) measurements in a subset of 100 patients showed greater daytime SBP reductions in the torasemide‐PR group (128.4 ± 9.9 mmHg vs. 133.5 ± 10.4 mmHg, P < 0.05). Safety and tolerability of both formulations were similar.

Matèries

Medicaments d'alliberament retardat, Pressió sanguínia

Matèries (anglès)

Delayed-action drugs, Blood pressure

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Articles publicats en revistes (Medicina)

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ROCA CUSACHS, Alex, ARACIL VILAR, Joaquín, CALVO GÓMEZ, Carlos, VAQUER PÉREZ, José vicente, LAPORTA CRESPO, Félix, ROJAS SERRANO, María josé, GUGLIETTA, Antonio, GROPPER, Savion, SOBRINO, Javier. Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release. _Cardiovascular Therapeutics_. 2008. Vol. 26, núm. 2, pàgs. 91-100. [consulta: 24 de gener de 2026]. ISSN: 1755-5914. [Disponible a: https://hdl.handle.net/2445/150971]

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