Miniatura

Fitxers

Cortes_N_PLoS_Negl_Trop_Dis_2020.pdf (1.07 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2020

Llicència de publicació

cc by (c) Cortes Serra, Nuria et al, 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183635

Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/ 10.1371/journal.pntd.0008370

Resum

"Chagas disease (CD) and tuberculosis (TB) are important health problems in Bolivia. Current treatments for both infections require a long period of time, and adverse drug reactions (ADRs) are frequent. This study aims to strengthen the Bolivian pharmacovigilance system, focusing on CD and TB. A situation analysis of pharmacovigilance in the Department of Cochabamba was performed. The use of a new local case report form (CRF) was implemented, together with the CRF established by the Unidad de Medicamentos y Tecnolog\xC3\xADa en Salud (UNIMED), in several healthcare centers. Training and follow-up on drug safety monitoring and ADR reporting was provided to all health professionals involved in CD and TB treatment. A comparative analysis of the reported ADRs using the CRF provided by UNIMED, the new CRF proposal, and medical records, was also performed. Our results showed that out of all patients starting treatment for CD, 37.9% suffered ADRs according to the medical records, and 25.3% of them were classified as moderate/severe (MS). Only 47.4% of MS ADRs were reported to UNIMED. Regarding TB treatment, 9.9% of all patients suffered ADRs, 44% of them were classified as MS, and 75% of MS ADRs were reported to UNIMED. These findings show that the reinforcement of the Bolivian pharmacovigilance system is an ambitious project that should involve a long-term perspective and the engagement of national health workers and other stakeholders at all levels. Continuity and perseverance are essential to achieve a solid ADR reporting system, improving patient safety, drug efficacy and adherence to treatment."

Matèries

Malaltia de Chagas, Tuberculosi, Bolívia

Matèries (anglès)

Chagas' disease, Tuberculosis, Bolivia

Citació

Col·leccions

Articles publicats en revistes (ISGlobal)

Citació

CORTES SERRA, Nuria, SARAVIA, Ruth, GRÁGEDA, Rosse mary, APAZA, Amílcar, GONZÁLEZ, Jorge armando, RÍOS, Brenda, GASCON, Joaquim, TORRICO, Faustino, PINAZO, Maria-jesus. Strengthening the Bolivian pharmacovigilance system: New
surveillance strategies to improve care for Chagas disease and
tuberculosis.. _PLoS Neglected Tropical Diseases_. 2020. Vol.  vol 14, núm. num. [consulta: 23 de gener de 2026]. ISSN: 1935-2735. [Disponible a: https://hdl.handle.net/2445/183635]

Exportar metadades

JSON - METS

Compartir registre