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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/198351
Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches
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Lipid droplets (LDs) are spherical, single sheet phospholipid-bound organelles that store neutral lipids in all eukaryotes and some prokaryotes. Initially conceived as relatively inert depots for energy and lipid precursors, these highly dynamic structures play active roles in homeostatic functions beyond metabolism, such as proteostasis and protein turnover, innate immunity and defense. A major share of the knowledge behind this paradigm shift has been enabled by the use of systematic molecular profiling approaches, capable of revealing and describing these non-intuitive systems-level relationships. Here, we discuss these advances and some of the challenges they entail, and highlight standing questions in the field.Copyright © 2022 Sánchez-Álvarez, del Pozo, Bosch and Pol.
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SÁNCHEZ ÁLVAREZ, Miguel, et al. Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches. Frontiers In Cell And Developmental Biology. 2022. Vol. 10. ISSN 2296-634X. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/198351