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Insights Into the Biogenesis and Emerging_FrontierInCellAndDevelopmental.pdf (2.36 MB)

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2022-06-08

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cc by (c) Sánchez Álvarez, Miguel et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198351

Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches

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Recurs relacionat

https://doi.org/10.3389/fcell.2022.901321

Resum

Lipid droplets (LDs) are spherical, single sheet phospholipid-bound organelles that store neutral lipids in all eukaryotes and some prokaryotes. Initially conceived as relatively inert depots for energy and lipid precursors, these highly dynamic structures play active roles in homeostatic functions beyond metabolism, such as proteostasis and protein turnover, innate immunity and defense. A major share of the knowledge behind this paradigm shift has been enabled by the use of systematic molecular profiling approaches, capable of revealing and describing these non-intuitive systems-level relationships. Here, we discuss these advances and some of the challenges they entail, and highlight standing questions in the field.Copyright © 2022 Sánchez-Álvarez, del Pozo, Bosch and Pol.

Matèries

Lípids, Biomolècules

Matèries (anglès)

Lipids, Biomolecules

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Col·leccions

Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SÁNCHEZ ÁLVAREZ, Miguel, POZO, Miguel ángel del, BOSCH, Marta, POL, Albert. Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches. _Frontiers In Cell And Developmental Biology_. 2022. Vol. 10. [consulta: 7 de febrer de 2026]. ISSN: 2296-634X. [Disponible a: https://hdl.handle.net/2445/198351]

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