Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

TFG_Güell_Brugués_Arnau.pdf (1.45 MB)

Document type

Bachelor thesis

Publication date

2023-06-12

Publication license

cc-by-nc-nd (c) Güell Brugués, Arnau, 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/199610

Analysis of slow waves in the cerebral cortex during aging

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

Abstract

Slow oscillations, which are the default mode of the cortex and the main oscillation in slow-wave sleep, may be affected by aging. In this project, aging effect on the properties of the cortical slow oscillation is studied in 3, 7, 15 and 20 months of age sedated mice with Slowpy, a specialized pipeline for slow oscillations. Results show that aging affects the duration of Ups and Downs, as they slightly decrease with age, as well as the is an increase of the firing rate of the Up states with age. These effects can be explained by several biological and physiological reasons, such as changes in neuronal excitability and network connectivity. However, the effects of aging in functional connectivity remain unclear with this project, as this relationship has not been directly addressed in this study.

Description

Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Gutiérrez Gálvez, Agustí, Sánchez Vives, Maria V., Manasanch Berengué, Arnau

Subject

Enginyeria biomèdica, Ones, Treballs de fi de grau, Escorça cerebral, Xarxes neuronals (Neurobiologia), Edats de la vida

Subject (English)

Biomedical engineering, Waves, Bachelor's theses, Cerebral cortex, Neural networks (Neurobiology), Human life cycle

Citation

Collections

Treballs Finals de Grau (TFG) - Enginyeria Biomèdica

Citation

GÜELL BRUGUÉS, Arnau. Analysis of slow waves in the cerebral cortex during aging. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/199610

Export metadata

JSON - METS

Share record