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Invasive pneumococcal disease in children: Risk factors and vaccine effectiveness
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Invasive pneumococcal disease (IPD) has high morbidity and mortality worldwide. The overall incidence of IPD in Catalonia in 2005-2009 was 16.6 per 100,000 persons-year, 66.4 in children aged < 2 years and 50.7 in children aged 2-4 years. 7-valent pneumococcal conjugate vaccine (PCV7) coverage in Catalonia is intermediate. A prospective matched case-control study in children aged 3-59 months treated at two hospitals in Catalonia during 2007-2009 was performed. Potential risk factors for IPD and PCV7 effectiveness in preventing IPD were investigated. 293 cases and 785 controls were included. Attendance at daycare or school was a risk factor for IPD (aOR 3.07, 95% CI 1.97-4.78) and the effectiveness of PCV7 against vaccine serotypes was 93.7% (95% CI 51.8 -99.2).
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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042
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CIRUELA, Pilar, et al. Invasive pneumococcal disease in children: Risk factors and vaccine effectiveness. Recent Advances in Pharmaceutical Sciences VI. 2016. Vol. Editors: Diego Muñoz Torrero, num. Ángeles Manresa Presas, pags. 91-110. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/104142