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Accepted version

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2022-11-01

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cc by-nc-nd (c) Elsevier, 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/196881

The role of lipids in cancer progression and metastasis

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https://doi.org/10.1016/j.cmet.2022.09.023

Abstract

Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.

Subject

Metabolisme dels lípids, Metàstasi, Tractament adjuvant del càncer

Subject (English)

Lipid metabolism, Metastasis, Adjuvant treatment of cancer

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

MARTÍN PÉREZ, Miguel, et al. The role of lipids in cancer progression and metastasis. Cell Metabolism. 2022. Vol. 34, num. 11, pags. 1675-1699. ISSN 1550-4131. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/196881

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