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2024-01-04

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cc by (c) Narváez, Javier et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/206248

Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy

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https://doi.org/10.1186/s13075-023-03254-w

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Objective: To investigate the usefulness of F-18-FDG PET-CT for assessing large-vessel (LV) involvement in patients with suspected giant cell arteritis (GCA) and a negative temporal artery biopsy (TAB).Methods: A retrospective review of our hospital databases was conducted to identify patients with suspected GCA and negative TAB who underwent an F-18-FDG PET-CT in an attempt to confirm the diagnosis. The gold standard for GCA diagnosis was clinical confirmation after a follow-up period of at least 12 months.Results: Out of the 127 patients included in the study, 73 were diagnosed with GCA after a detailed review of their medical records. Of the 73 patients finally diagnosed with GCA, F-18-FDG PET-CT was considered positive in 61 cases (83.5%). Among the 54 patients without GCA, F-18-FDG PET-CT was considered positive in only eight cases (14.8%), which included 1 case of Erdheim-Chester disease, 3 cases of IgG4-related disease, 1 case of sarcoidosis, and 3 cases of isolated aortitis. Overall, the diagnostic performance of F-18-FDG PET-CT for assessing LV involvement in patients finally diagnosed with GCA and negative TAB yielded a sensitivity of 83.5%, specificity of 85.1%, and a diagnostic accuracy of 84% with an area under the ROC curve of 0.844 (95% CI: 0.752 to 0.936). The sensitivity was 89% in occult systemic GCA and 100% in extracranial LV-GCA.Conclusion: Our study confirms the utility of F-18-FDG PET-CT in patients presenting with suspected GCA and a negative TAB by demonstrating the presence of LV involvement across different subsets of the disease.

Matèries

Arteritis de cèl·lules gegants, Tomografia per emissió de positrons

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Giant cell arteritis, Positron emission tomography

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

NARVÁEZ, Javier, et al. Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy. Arthritis Research & Therapy. 2024. Vol. 26, num. 1. ISSN 1478-6362. [consulted: 23 of May of 2026]. Available at: https://hdl.handle.net/2445/206248

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