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2022-12-24

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cc-by (c) Bonelli Blasco, Joaquin Daniel et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/197404

Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis

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https://doi.org/10.3390/pharmaceutics15010058

Resum

Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs' surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer.

Matèries

Biocompatibilitat, Tumors, Poliuretans

Matèries (anglès)

Biocompatibility, Tumors, Polyurethanes

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Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

BONELLI BLASCO, Joaquin daniel, VELASCO DE ANDRÉS, María, ISIDRO, Neus, BAYÓ, Cristina, CHUMILLAS, Sergi, CARRILLO-SERRADELL, Laura, CASADÓ LLOMBART, Sergi, MOK, Cheryl, BENÍTEZ-RIBAS, Daniel, LOZANO SOTO, Francisco, ROCAS SOROLLA, Josep, MARCHÁN SANCHO, Vicente. Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis. _Pharmaceutics_. 2022. Vol. 15, núm. 1, pàgs. 58. [consulta: 14 de gener de 2026]. ISSN: 1999-4923. [Disponible a: https://hdl.handle.net/2445/197404]

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