Carregant...
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123494
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.
Matèries
Matèries (anglès)
Citació
Citació
BYRNE, Annette t., ALFÉREZ, Denis g., AMANT, Frédéric, ANNIBALI, Daniela, ARRIBAS, Joaquín v. (vicente), BIANKIN, Andrew v., BRUNA, Alejandra, BUDINSKÁ, Eva, CALDAS, Carlos, CHANG, David k., CLARKE, Robert b., CLEVERS, Hans, COUKOS, George, DANGLES MARIE, Virginie, ECKHARDT, S. gail, GONZÁLEZ SUÁREZ, Eva, HERMANS, Els, HIDALGO, Manuel, JARZABEK, Monika a., JONG, Steven de, JONKERS, Jos, KEMPER, Kristel, LANFRANCONE, Luisa, MÆLANDSMO, Gunhild mari, MARANGONI, Elisabetta, MARINE, Jean-christophe, MEDICO, Enzo, NORUM, Jens henrik, PALMER, Héctor g., PEEPER, Daniel s., PELICCI, Pier giuseppe, PIRIS GIMENEZ, Alejandro, ROMAN ROMAN, Sergio, RUEDA, Oscar m., SEOANE SUÁREZ, Joan, SERRA ELIZALDE, Violeta, SOUCEK, Laura, VANHECKE, Dominique, VILLANUEVA GARATACHEA, Alberto, VINOLO, Emilie, BERTOTTI, Andrea, TRUSOLINO, Livio. Interrogating open issues in cancer precision medicine with patient-derived xenografts. _Nature Reviews Cancer_. 2017. Vol. 17, núm. 254–268. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/123494]