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Byrne_et_al_NRC_2018.pdf (1.8 MB)

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2017-01-20

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123494

Interrogating open issues in cancer precision medicine with patient-derived xenografts

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Recurs relacionat

http://dx.doi.org/10.1038/nrc.2016.140

Resum

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.

Matèries

Càncer, Marcadors tumorals

Matèries (anglès)

Cancer, Tumor markers

Citació

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BYRNE, Annette t., ALFÉREZ, Denis g., AMANT, Frédéric, ANNIBALI, Daniela, ARRIBAS, Joaquín v. (vicente), BIANKIN, Andrew v., BRUNA, Alejandra, BUDINSKÁ, Eva, CALDAS, Carlos, CHANG, David k., CLARKE, Robert b., CLEVERS, Hans, COUKOS, George, DANGLES MARIE, Virginie, ECKHARDT, S. gail, GONZÁLEZ SUÁREZ, Eva, HERMANS, Els, HIDALGO, Manuel, JARZABEK, Monika a., JONG, Steven de, JONKERS, Jos, KEMPER, Kristel, LANFRANCONE, Luisa, MÆLANDSMO, Gunhild mari, MARANGONI, Elisabetta, MARINE, Jean-christophe, MEDICO, Enzo, NORUM, Jens henrik, PALMER, Héctor g., PEEPER, Daniel s., PELICCI, Pier giuseppe, PIRIS GIMENEZ, Alejandro, ROMAN ROMAN, Sergio, RUEDA, Oscar m., SEOANE SUÁREZ, Joan, SERRA ELIZALDE, Violeta, SOUCEK, Laura, VANHECKE, Dominique, VILLANUEVA GARATACHEA, Alberto, VINOLO, Emilie, BERTOTTI, Andrea, TRUSOLINO, Livio. Interrogating open issues in cancer precision medicine with patient-derived xenografts. _Nature Reviews Cancer_. 2017. Vol. 17, núm. 254–268. [consulta: 8 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/123494]

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