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Reply to von Reyn and Horsburgh

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The study by Muñoz et al [1] demonstrates that the need for treatment of healthy household contacts of active tuberculosis can be safely reduced by 20% when an interferon γ release assay is used to exclude false-positive tuberculin skin test (TST) results. Because the study was conducted in Spain, 28% of trial participants had been previously immunized with Bacille Calmette Guerin (BCG) vaccine, a factor that seemed to be the predominant cause of false-positive TST results. The authors surmise that the remaining proportion of false-positive results may have been due to exposure to nontuberculous mycobacteria (NTM).

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SANTÍN CEREZALES, Miguel, MUÑOZ, Laura and TEBÉ, Cristian. Reply to von Reyn and Horsburgh. Clinical Infectious Diseases. 2018. Vol. 67, num. 8, pags. 1308-1309. [consulted: 11 of November of 2026]. Available at: https://hdl.handle.net/2445/172438

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