Miniatura

Fitxers

639620.pdf (282.06 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2013-06-24

Llicència de publicació

cc-by-nc-nd (c) Killick, Emma et al., 2013
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/100160

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1038/srep02059

Resum

Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA > 3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.

Matèries

Càncer de pròstata, Factors de risc en les malalties, Marcadors tumorals, Antigen específic de la pròstata

Matèries (anglès)

Prostate cancer, Risk factors in diseases, Tumor markers, Prostate-specific antigen

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

KILLICK, Emma, MORGAN, Richard, LAUNCHBURY, Francesca, BANCROFT, Elizabeth k., PAGE, Elizabeth, CASTRO, Elena, KOTE-JARAI, Zsofia, APRIKIAN, Armen, BLANCO GUILLERMO, Ignacio, CLOWES, Virginia, DOMCHEK, Susan m., DOUGLAS, Fiona, ECCLES, Diana, EVANS, D. gareth, HARRIS, Marion, KIRK, Judy, LAM, Jimmy, LINDEMAN, Geoffrey j., MITCHELL, Gillian, PACHTER, Nicholas, SELKIRK, Christina, TUCKER, Kathy, ZGAJNAR, Janaz, EELES, Rosalind a., PANDHA, Hardev. Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men. _Scientific Reports_. 2013. Vol. 3, núm. 2059. [consulta: 24 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/100160]

Exportar metadades

JSON - METS

Compartir registre