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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174195
Intratumoral heterogeneity and clonal evolution in liver cancer
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Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and immune cells. We investigate how these interactions reflect intra-tumor heterogeneity (ITH) by correlating regional neo-epitope and viral antigen burden with the regional adaptive immune response. Regional expression of passenger mutations dominantly recruits adaptive responses as opposed to hepatitis B virus and cancer-testis antigens. We detect different clonal expansion of the adaptive immune system in distant regions of the same tumor. An ITH-based gene signature improves single-biopsy patient survival predictions and an expression survey of 38,553 single cells across 7 regions of 2 patients further reveals heterogeneity in liver cancer. These data quantify transcriptomic ITH and how the different components of the HCC ecosystem interact during cancer evolution.
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LOSIC, Bojan, CRAIG, Amanda j., VILLACORTA-MARTIN, Carlos, MARTINS-FILHO, Sebastiao n., AKERS, Nicholas, CHEN, Xintong, AHSEN, Mehmet eren, VON FELDEN, Johann, LABGAA, Ismail, AVOLA, Delia d', ALLETTE, Kimaada, LIRA, Sergio a., FURTADO, Glaucia c., GARCIA-LEZANA, Teresa, RESTREPO, Paula, STUECK, Ashley, WARD, Stephen c., FIEL, Maria i., HIOTIS, Spiros p., GUNASEKARAN, Ganesh, SIA, Daniela, SCHADT, Eric e., SEBRA, Robert, SCHWARTZ, Myron, LLOVET I BAYER, Josep maria, THUNG, Swan n., STOLOVITZKY, Gustavo, VILLANUEVA, Augusto. Intratumoral heterogeneity and clonal evolution in liver cancer. _Nature Communications_. 2020. Vol. 11, núm. 291. [consulta: 20 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/174195]