Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124207
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
MicroRNAs (miRNAs) interact with 3'-untranslated regions of messenger RNAs to restrict expression of most protein-coding genes during normal development and cancer. RNA-binding proteins (RBPs) can control the biogenesis, stability and activity of miRNAs. Here we identify RBM38 in a genetic screen for RBPs whose expression controls miRNA access to target mRNAs. RBM38 is induced by p53 and its ability to modulate miRNA-mediated repression is required for proper p53 function. In contrast, RBM38 shows lower propensity to block the action of the p53-controlled miR-34a on SIRT1. Target selectivity is determined by the interaction of RBM38 with uridine-rich regions near miRNA target sequences. Furthermore, in large cohorts of human breast cancer, reduced RBM38 expression by promoter hypermethylation correlates with wild-type p53 status. Thus, our results indicate a novel layer of p53 gene regulation, which is required for its tumour suppressive function.
Subject
Subject (English)
Citation
Citation
LÉVEILLÉ, Nicolas, et al. Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nature Communications. 2011. Vol. 2, num. 513. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/124207