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Article

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2017-11-22

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cc-by (c) Fernández Dueñas, Víctor et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/148041

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease

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https://doi.org/10.3389/fnins.2017.00652

Abstract

Parkinson's disease (PD) is a progressive, neurodegenerative disorder that affects ~1% of individuals over the age of 60, which turns to 5% in subjects up to 85 years (de Lau and Breteler, 2006). On the other hand, a form of PD, called early-onset PD (EOPD), arises at an earlier age (<45; Bonifati et al., 2005; Ylikotila et al., 2015). EOPD patients generally display a slower progression of the disease and present a better response to dopaminergic treatments; however, they may finally develop a full PD symptomatology (i.e., bradykinesia, resting tremor, muscular rigidity and postural instability, drug-induced dyskinesia; Olgiati et al., 2016).

Subject

Malaltia de Parkinson, Oligòmers, Adenosina

Subject (English)

Parkinson's disease, Oligomers, Adenosine

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citation

FERNÁNDEZ DUEÑAS, Víctor, et al. Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease. Frontiers in Neuroscience. 2017. Vol. 11, num. 652. ISSN 1662-4548. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/148041

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