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Tort-Merino et al. (2025).pdf (1.58 MB)

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2025-03-01

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cc-by-nc (c) Tort Merino, Adrià et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223948

Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study

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INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2-year follow-up. We used linear mixed-effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects. RESULTS The A beta+ group showed reduced practice effects in verbal learning (beta = -1.14, SE = 0.40, p = 0.0046) and memory function (beta = -0.56, SE = 0.19, p = 0.0035), as well as in language tasks (beta = -0.59, SE = 0.19, p = 0.0027). DISCUSSION Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials. Highlights This was a multicenter study on practice effects in asymptomatic A beta+ individuals. We used LME models to analyze cognitive trajectories across multiple domains. Practice-effects reductions might be an indicator of subtle cognitive decline. Implications on clinical and research settings within the AD field are discussed.

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Malaltia d'Alzheimer, Trastorns de la cognició, Neuropsiquiatria geriàtrica

Matèries (anglès)

Alzheimer's disease, Cognition disorders, Geriatric neuropsychiatry

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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TORT MERINO, Adrià, PÉREZ MILLAN, Agnès, FALGÀS MARTÍNEZ, Neus, BORREGO ÉCIJA, Sergi, ESTELLER, Diana, BOSCH, Bea, CASTELLVÍ, Magdalena, JUNCÀ PARELLA, Jordi, VAL GUARDIOLA, Andrea, FERNÁNDEZ VILLULLAS, Guadalupe, ANTONELL BOIXADER, Anna, SANCHEZ-SAUDINOS, María belén, RUBIO GUERRA, Sara, ZHU, Nuole, GARCÍA MARTÍNEZ, María, POZUETA, Ana, ESTANGA, Ainara, ECAY TORRES, Mirian, LOPEZ DE LUIS, Carolina, TAINTA, Mikel, ALTUNA, Miren, RODRIGUEZ RODRIGUEZ, Eloy, SANCHEZ JUAN, Pascual, MARTINEZ LAGE, Pablo, LLEO, Alberto, FORTEA, Juan, ILLÁN GALA, Ignacio, BALASA, Mircea, LLADÓ PLARRUMANÍ, Albert, RAMI GONZÁLEZ, Lorena, SANCHEZ VALLE, Raquel. Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study. _Alzheimers & Dementia_. 2025. Vol. 21, núm. 3, pàgs. 70016. [consulta: 24 de novembre de 2025]. ISSN: 1552-5279. [Disponible a: https://hdl.handle.net/2445/223948]

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