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2020-07-01

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cc by (c) Dominguez Valentin et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/173632

Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database

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https://doi.org/10.3390/jcm9072290

Abstract

Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and to path_PMS2 carriers in 14/21 (67%). Regarding the involvement of stakeholders, there is global agreement (similar to 90%) that risk-reducing surgery should be offered to women, and that this discussion may involve gynecologists, genetic counselors and/or medical geneticists. Prescription of estrogen-only HRT is offered by 15/21 (71%) centers to women of variable age range (35-55 years). Conclusions: Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research.

Subject

Malalties hereditàries, Càncer d'endometri, Càncer d'ovari

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Genetic disorders, Endometrial cancer, Ovarian cancer

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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DOMINGUEZ VALENTIN, Mev, et al. Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database. Journal of Clinical Medicine. 2020. Vol. 9, num. 7. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/173632

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