Backtracking NOM1::ETV6 fusion to neonatal pathogenesis of t(7;12) (q36;p13) infant AML.

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dc.contributor.authorBousquets Muñoz, Pablo
dc.contributor.authorMolina, Òscar
dc.contributor.authorVarela, Ignacio
dc.contributor.authorÁlvarez-Eguiluz, Ángel
dc.contributor.authorFernández-Mateos, Javier
dc.contributor.authorGómez, Ana
dc.contributor.authorSánchez, Elena G.
dc.contributor.authorBalbín, Milagros
dc.contributor.authorRuano, David
dc.contributor.authorRamírez-Orellana, Manuel
dc.contributor.authorPuente, Xose S.
dc.contributor.authorMenéndez, Pablo
dc.contributor.authorVelasco-Hernandez, Talia
dc.date.accessioned2025-02-05T15:12:45Z
dc.date.available2025-02-05T15:12:45Z
dc.date.issued2024-05-17
dc.date.updated2025-02-05T15:12:45Z
dc.description.abstractThis work demonstrated the prenatal origin of the translocation t(7;12) giving rise to the ETV6-NOM1 fusion protein, in a 5-month-old patient with acute myeloblastic leukemia using an umbilical cord blood (CB) sample from the patient stored at birth. Our findings revealed the presence of a specific t(7;12)/ETV6-NOM1 fusion in both CD34+ hematopoietic stem/progenitor cells and in the CD34-CD33+ myeloid cellular compartment isolated from the patient’s umbilical CB.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec752720
dc.identifier.issn0887-6924
dc.identifier.pmid38806630
dc.identifier.urihttps://hdl.handle.net/2445/218527
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41375-024-02293-9
dc.relation.ispartofLeukemia, 2024, vol. 38, p. 1808-1812
dc.relation.urihttps://doi.org/10.1038/s41375-024-02293-9
dc.rightscc by (c) Bousquets-Muñoz, P. et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationLeucèmia mieloide
dc.subject.classificationCromosomes humans
dc.subject.classificationInfants
dc.subject.otherMyeloid leukemia
dc.subject.otherHuman chromosomes
dc.subject.otherChildren
dc.titleBacktracking NOM1::ETV6 fusion to neonatal pathogenesis of t(7;12) (q36;p13) infant AML.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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