Miniatura

Fitxers

1-s2.0-S0010440X22000219-main.pdf (557.62 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-04-01

Llicència de publicació

cc by-nc-nd (c) Benatti, Beatrice et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/186651

The role of gender in a large international OCD sample: A Report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) Network

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.comppsych.2022.152315

Resum

Introduction: Obsessive-compulsive disorder (OCD) is characterized by a range of phenotypic expressions. Gender may be a relevant factor in mediating the disorder's heterogeneity. The aim of the present report was to explore a large multisite clinical sample of OCD patients, hypothesizing existing demographic, geographical and clinical differences between male and female patients with OCD.& nbsp;Methods: Socio-demographic and clinical variables of 491 adult OCD outpatients recruited in the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network were investigated with a retrospective analysis on a previously gathered set of data from eleven countries worldwide. Patients were assessed throughstructured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Montgomery-Asberg Depression Rating Scale (MADRS) and the Self-rating Depression Scale (SDS).& nbsp;Results: Among females, adult onset (> 18 years old) was significantly over-represented (67% vs. 33%, p < 0.005), and females showed a significantly older age at illness onset compared with males (20.85 +/- 10.76 vs. 17.71 +/- 8.96 years, p < 0.005). Females also had a significantly lower education level than males (13.09 +/- 4.02 vs. 13.98 +/- 3.85 years; p < 0.05), a significantly higher rate of being married (50.8% vs. 33.5%; p < 0.001) and a higher rate of living with a partner (47.5% vs. 37.6%; p < 0.001) than males. Nonetheless, no significant gender dif-ferences emerged in terms of the severity of OCD symptoms nor in the severity of comorbid depressive symptoms. No predictive effect of gender was found for Y-BOCS, MADRS and SDS severity.& nbsp;Discussion/Conclusions.: Our findings showed significant differences between genders in OCD. A sexually dimorphic pattern of genetic susceptibility may have a crucial role to OCD clinical heterogeneity, potentially requiring different specific therapeutic strategies. Further research is warranted to validate gender as an important determinant of the heterogeneity in OCD.

Matèries

Neurosi obsessiva, Trastorns de la conducta, Gender studies

Matèries (anglès)

Obsessive-compulsive disorder, Behavior disorders, Estudis de gènere

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BENATTI, Beatrice, GIRONE, Nicolaja, CELEBRE, Laura, VISMARA, Matteo, HOLLANDER, Eric, FINEBERG, Naomi a., STEIN, Dan j., NICOLINI, Humberto, LANZAGORTA, Nuria, MARAZZITI, Donatella, PALLANTI, Stefano, VAN AMERINGEN, Michael, LOCHNER, Christine, KARAMUSTAFALIOGLU, Oguz, HRANOV, Luchezar, FIGEE, Martin, DRUMMOND, Lynne m., GRANT, Jon e., DENYS, Damiaan, FONTENELLE, Leonardo f., MENCHÓN MAGRIÑÁ, José manuel, ZOHAR, Joseph, RODRIGUEZ, Carolyn i., DELL'OSSO, Bernardo. The role of gender in a large international OCD sample: A Report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) Network. _Comprehensive Psychiatry_. 2022. Vol. 116, núm. 152315. [consulta: 18 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/186651]

Exportar metadades

JSON - METS

Compartir registre