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Prevalent sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH
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We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C+ base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C+ base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes.
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MIR MORRO, Bartomeu, SERRANO, Israel, BUITRAGO OSPINA, Diana camila, OROZCO LÓPEZ, Modesto, ESCAJA SÁNCHEZ, Nuria, GONZÁLEZ, Carlos. Prevalent sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH. _Journal of the American Chemical Society_. 2017. Vol. 139, núm. 40, pàgs. 13985-13988. [consulta: 23 de gener de 2026]. ISSN: 0002-7863. [Disponible a: https://hdl.handle.net/2445/117632]