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2021-12-30

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cc-by (c) Bardallo, Raquel G. et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230098

Nrf2 and oxidative stress in liver ischemia/reperfusion injury

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Recurs relacionat

https://doi.org/10.1111/febs.16336

Resum

In response to stress signal, nuclear factor-erythroid 2-related factor 2 (Nrf2) induces the expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is strictly regulated through a variety of mechanisms, including regulation of Keap1-Nrf2 stability, transcriptional regulation (NF-ĸB, ATF3, ATF4), and post-transcriptional regulation (miRNA), evidencing that transcriptional responses of Nrf2 are critical for the maintenance of homeostasis. Ischemia-reperfusion (IR) injury is a major cause of graft loss and dysfunction in clinical transplantation and organ resection. During the IR process, the generation of reactive oxygen species (ROS) leads to damage from oxidative stress, oxidation of biomolecules, and mitochondrial dysfunction. Oxidative stress can trigger apoptotic and necrotic cell death. Stress factors also result in the assembly of the inflammasome protein complex and the subsequent activation and secretion of proinflammatory cytokines. After Nrf2 activation, the downstream antioxidant upregulation can act as a primary cellular defense against the cytotoxic effects of oxidative stress and help to promote hepatic recovery during IR. The complex crosstalk between Nrf2 and cellular pathways in liver IR injury and the potential therapeutic target of the Nrf2 inducers will be discussed in the present review.

Matèries

Estrès (Fisiologia), Estrès oxidatiu, Mort cel·lular

Matèries (anglès)

Stress (Physiology), Oxidative stress, Cell death

Citació

Col·leccions

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BARDALLO, Raquel G., et al. Nrf2 and oxidative stress in liver ischemia/reperfusion injury. The FEBS Journal. 2021. Vol. 289, num. 18, pags. 5463-5479. ISSN 1742-464X. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/230098

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