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Article

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Published version

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2023-03-16

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cc-by-nc-nd (c) Parra-Vargas, M. et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216959

The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology

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https://doi.org/10.1016/j.molmet.2023.101707

Abstract

Background/purpose: Litter size is a biological variable that strongly influences adult physiology in rodents. Despite evidence from previous decades and recent studies highlighting its major impact on metabolism, information about litter size is currently underreported in the scientific literature. Here, we urge that this important biological variable should be explicitly stated in research articles. Results/conclusion: Below, we briefly describe the scientific evidence supporting the impact of litter size on adult physiology and outline a series of recommendations and guidelines to be implemented by investigators, funding agencies, editors in scientific journals, and animal suppliers to fill this important gap.

Subject

Models animals en la investigació, Adults, Ratolins (Animals de laboratori), Fisiologia

Subject (English)

Animal models in research, Adulthood, Mice (Laboratory animals), Physiology

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Articles publicats en revistes (Ciències Fisiològiques)

Citation

PARRA-VARGAS, Marcela, et al. The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Molecular Metabolism. 2023. Vol. 71. ISSN 2212-8778. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/216959

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