The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology

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dc.contributor.authorParra-Vargas, Marcela
dc.contributor.authorBouret, Sebastien G.
dc.contributor.authorBrunning, Jens C.
dc.contributor.authorMoura, Egberto G.
dc.contributor.authorGarland, Theodore Jr.
dc.contributor.authorLisboa, Patricia C.
dc.contributor.authorOzanne, Susan E.
dc.contributor.authorPatti, Mary-Elizabeth
dc.contributor.authorPlagemann, Andreas
dc.contributor.authorSpeakman, John R.
dc.contributor.authorTena-Sempere, Manuel
dc.contributor.authorVergely, Catherine
dc.contributor.authorZeltser, Lori M.
dc.contributor.authorJiménez-Chillaron, Josep C.
dc.date.accessioned2024-12-05T19:22:46Z
dc.date.available2024-12-05T19:22:46Z
dc.date.issued2023-03-16
dc.date.updated2024-12-05T19:22:46Z
dc.description.abstractBackground/purpose: Litter size is a biological variable that strongly influences adult physiology in rodents. Despite evidence from previous decades and recent studies highlighting its major impact on metabolism, information about litter size is currently underreported in the scientific literature. Here, we urge that this important biological variable should be explicitly stated in research articles. Results/conclusion: Below, we briefly describe the scientific evidence supporting the impact of litter size on adult physiology and outline a series of recommendations and guidelines to be implemented by investigators, funding agencies, editors in scientific journals, and animal suppliers to fill this important gap.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec739761
dc.identifier.issn2212-8778
dc.identifier.pmid36933618
dc.identifier.urihttps://hdl.handle.net/2445/216959
dc.language.isoeng
dc.publisherElsevier GmbH
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.molmet.2023.101707
dc.relation.ispartofMolecular Metabolism, 2023, vol. 71
dc.relation.urihttps://doi.org/10.1016/j.molmet.2023.101707
dc.rightscc-by-nc-nd (c) Parra-Vargas, M. et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationModels animals en la investigació
dc.subject.classificationAdults
dc.subject.classificationRatolins (Animals de laboratori)
dc.subject.classificationFisiologia
dc.subject.otherAnimal models in research
dc.subject.otherAdulthood
dc.subject.otherMice (Laboratory animals)
dc.subject.otherPhysiology
dc.titleThe long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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