Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer

Abstract

Cancer remains a global health concern, being one of the leading causes of premature death worldwide. In 2020, around 19 million people were diagnosed with cancer, leading to approximately 10 million deaths [1], [2]. Conventional cancer therapies, including chemotherapy and radiotherapy, often exhibit adverse effects and suboptimal treatment outcomes. Specifically, chemotherapy is frequently administered to over 50 % of cancer patients, but it can simultaneously impact both healthy and cancerous cells, causing significant side effects. Moreover, these therapies can induce chemoresistance, compromising their effectiveness over time [3], [4]. As a result, there is an urgent need for the development of innovative therapeutic strategies to address these limitations.