El pròxim dijous 7 de maig, el Dipòsit Digital no estarà operatiu de 8:00 a 12:00 h per tasques d'actualització. Disculpeu les molèsties.
El próximo jueves 7 de mayo, el Dipòsit Digital no estará operativo de 8:00 a 12:00 h debido a tareas de actualización. Disculpen las molestias.
Our digital repository will be temporarily unavailable on Thursday, May 7th, from 8:00 a.m. to 12:00 p.m. due to a system update.
 
Miniatura

Fitxers

936414.pdf (675.2 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2026-02-10

Llicència de publicació

cc-by-nc-nd (c) Kubeczko, Marcin et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229244

Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41523-026-00909-0

Resum

Trastuzumab, pertuzumab, and a taxane (THP) has been the standard first-line therapy for HER2+ advanced breast cancer for over a decade. With new regimens emerging, genomic tools like HER2DX may help identify patients who benefit durably from THP versus those requiring intensification. Here, baseline tumor tissue from 122 patients with HER2+ treated with THP in Poland was tested with HER2DX. A previously published Spanish real-world cohort (n = 93) was added to generate a combined cohort (n = 215). Univariable analyses were performed in the Polish cohort, and multivariable Cox and logistic regression models were applied to the combined cohort. A HER2DX metastatic prognostic score was trained on overall survival (OS) in the Spanish cohort and validated in the Polish cohort. In the Polish cohort, high ERBB2 mRNA scores were associated with significantly longer real-world progression-free survival (rwPFS) (33.8 vs. 17.9 months; hazard ratio [HR] 0.57; p = 0.022) and real-world overall survival (rwOS) (75.1 vs. 40.2; HR 0.48; p = 0.009). In the combined cohort, ERBB2 high-score tumors showed prolonged rwPFS (33.8 vs. 12.5; HR 0.50; p < 0.001) and rwOS (not reached vs. 37.1; HR 0.36; p < 0.001), and higher rwORR (84.4% vs. 52.0%; p < 0.001). Prognostic value was independent of clinical variables, including number of metastatic sites. Subgroup analyses showed particularly favorable outcomes in patients with <3 sites (median rwPFS 51.7 vs. 20.3 months). The HER2DX metastatic prognostic score outperformed ERBB2 alone in the validation cohort. In conclusion, the HER2DX ERBB2 mRNA score provides independent prognostic information in HER2+ advanced breast cancer treated with THP. The HER2DX metastatic prognostic score further improves prognostic accuracy.

Matèries

Genòmica, Pronòstic mèdic, Càncer de mama

Matèries (anglès)

Genomics, Prognosis, Breast cancer

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

KUBECZKO, Marcin, COBO, Sandra, SÁNCHEZ BAYONA, Rodrigo, PYCINSKI, Bartlomiej, SOBERINO, Jesús, CHMIELIK, Ewa, SANFELIU, Esther, REY, Maria, PARDO, Francisco, AGUIRRE, Ángela, CASTILLO, Oleguer, LESNIAK, Aleksandra, OCZKO-WOJCIECHOWSKA, Malgorzata, CARCELERO SAN MARTIN, Esther, ADAMO, Barbara, VIDAL LOSADA, Maria jesús, BERGAMINO SIRVÉN, Milana, MAUES, Julia, VILLACAMPA, Guillermo, PARÉ, Laia, VILLAGRASA, Patricia, CIRUELOS, Eva, PRAT APARICIO, Aleix, JARZAB, Michal, BRASÓ-MARISTANY, Fara. Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane. _npj Breast Cancer_. 2026. Vol. 12, núm. 1. [consulta: 6 de maig de 2026]. ISSN: 2374-4677. [Disponible a: https://hdl.handle.net/2445/229244]

Exportar metadades

JSON - METS

Compartir registre