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2019-08-07

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cc-by (c) García-Cano, Jesús et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/146580

HERCing: structural and functional relevance of the large HERC ubiquitin ligases

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Recurs relacionat

https://doi.org/10.3389/fphys.2019.01014

Resum

Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the superfamily of ubiquitin ligases. HERC proteins are divided into two subfamilies, Large and Small HERCs. Despite their similarities in terms of both structure and domains, these subfamilies are evolutionarily very distant and result from a convergence phenomenon rather than from a common origin. Large HERC genes, HERC1 and HERC2, are present in most metazoan taxa. They encode very large proteins (approximately 5,000 amino acid residues in a single polypeptide chain) that contain more than one RCC1-like domain as a structural characteristic. Accumulating evidences show that these unusually large proteins play key roles in a wide range of cellular functions which include neurodevelopment, DNA damage repair, and cell proliferation. To better understand the origin, evolution, and function of the Large HERC family, this minireview provides with an integrated overview of their structure and function and details their physiological implications. This study also highlights and discusses how dysregulation of these proteins is associated with severe human diseases such as neurological disorders and cancer.

Matèries

Càncer, Evolució, Neurobiologia, Ubiqüitina

Matèries (anglès)

Cancer, Evolution, Neurobiology, Ubiquitin

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Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GARCÍA-CANO, Jesús, MARTINEZ-MARTINEZ, Arturo, SALA GASTÓN, Joan, PEDRAZZA, Leonardo, ROSA LÓPEZ, José luis. HERCing: structural and functional relevance of the large HERC ubiquitin ligases. _Frontiers in Physiology_. 2019. Vol. 10, núm. 1014. [consulta: 12 de gener de 2026]. ISSN: 1664-042X. [Disponible a: https://hdl.handle.net/2445/146580]

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