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Photocontrol of endogenous glycine receptors in vivo

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dc.contributor.authorGomila, Alexandre M. J.
dc.contributor.authorRustler, Karin
dc.contributor.authorMaleeva, Galyna
dc.contributor.authorNin-Hill, Alba
dc.contributor.authorWutz, Daniel
dc.contributor.authorBautista-Barrufet, Antoni
dc.contributor.authorRovira, Xavier
dc.contributor.authorBosch, Miquel
dc.contributor.authorMukhametova, Elvira
dc.contributor.authorPetukhova, Elena
dc.contributor.authorPonomareva, Daria
dc.contributor.authorMukhamedyarov, Marat
dc.contributor.authorPeiretti, Franck
dc.contributor.authorAlfonso Prieto, Mercedes
dc.contributor.authorRovira i Virgili, Carme
dc.contributor.authorKönig, Burkhard
dc.contributor.authorBregestovski, Piotr
dc.contributor.authorGorostiza Langa, Pablo Ignacio
dc.date.accessioned2024-10-10T14:14:28Z
dc.date.available2024-10-10T14:14:28Z
dc.date.issued2020-11-19
dc.date.updated2024-10-10T14:14:28Z
dc.description.abstractGlycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec744515
dc.identifier.issn2451-9456
dc.identifier.urihttps://hdl.handle.net/2445/215662
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.chembiol.2020.08.005
dc.relation.ispartofCell Chemical Biology, 2020, vol. 27, p. 1425-1433
dc.relation.urihttps://doi.org/10.1016/j.chembiol.2020.08.005
dc.rightscc-by-nc-nd (c) Gomila, Alexandre MJ, et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationFotoquímica
dc.subject.classificationFotofarmacologia
dc.subject.otherPhotochemistry
dc.subject.otherPhotopharmacology
dc.titlePhotocontrol of endogenous glycine receptors in vivo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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