Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

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dc.contributor.authorWagner, Renate
dc.contributor.authorVeigel, Daniel
dc.contributor.authorProstling, K.
dc.contributor.authorStübiger, Gerald
dc.contributor.authorGrusch, Michael
dc.contributor.authorWeghuber, J.
dc.contributor.authorSinger, Christian F.
dc.contributor.authorKarlic, H.
dc.contributor.authorColomer, Ramón
dc.contributor.authorLópez-Rodríguez, María Luz
dc.contributor.authorBenhamú, Bellinda
dc.contributor.authorHegardt, Fausto
dc.contributor.authorSerra i Cucurull, Dolors
dc.contributor.authorGarcía Gómez, Jordi
dc.contributor.authorValent, Peter
dc.contributor.authorGrunt, Thomas
dc.date.accessioned2016-04-14T09:59:33Z
dc.date.available2016-09-29T22:01:15Z
dc.date.issued2015-09-28
dc.date.updated2016-04-14T09:59:39Z
dc.description.abstractThe metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.
dc.format.extent1 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec657043
dc.identifier.issn0959-8049
dc.identifier.urihttps://hdl.handle.net/2445/97402
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/S0959-8049(16)30154-X
dc.relation.ispartofEuropean Journal of Cancer, 2015, vol. 51, num. Supplement 3, p. S49-S49
dc.relation.urihttp://dx.doi.org/10.1016/S0959-8049(16)30154-X
dc.rightscc-by-nc-nd (c) Elsevier B.V., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationTrompes de Fal·lopi
dc.subject.classificationCàncer d'ovari
dc.subject.classificationMedicaments antineoplàstics
dc.subject.classificationÀcids grassos
dc.subject.otherFallopian tubes
dc.subject.otherOvarian cancer
dc.subject.otherAntineoplastic agents
dc.subject.otherFatty acids
dc.titleMolecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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