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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178994
Facial Onset Sensory and Motor Neuronopathy
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Purpose of review: To improve our clinical understanding of facial onset sensory and motor neuronopathy (FOSMN). Recent findings: We identified 29 new cases and 71 literature cases, resulting in a cohort of 100 patients with FOSMN. During follow-up, cognitive and behavioral changes became apparent in 8 patients, suggesting that changes within the spectrum of frontotemporal dementia (FTD) are a part of the natural history of FOSMN. Another new finding was chorea, seen in 6 cases. Despite reports of autoantibodies, there is no consistent evidence to suggest an autoimmune pathogenesis. Four of 6 autopsies had TAR DNA-binding protein (TDP) 43 pathology. Seven cases had genetic mutations associated with neurodegenerative diseases. Summary: FOSMN is a rare disease with a highly characteristic onset and pattern of disease progression involving initial sensory disturbances, followed by bulbar weakness with a cranial to caudal spread of pathology. Although not conclusive, the balance of evidence suggests that FOSMN is most likely to be a TDP-43 proteinopathy within the amyotrophic lateral sclerosis-FTD spectrum.
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DE BOER, Eva m.j., BARRITT, Andrew w., ELAMIN, Marwa, ANDERSON, Stuart j., BROAD, Rebecca, NISBET, Angus, GOEDEE, H. stephan, VÁZQUEZ COSTA, Juan f., PRUDLO, Johannes, VEDELER, Christian a., PARDO FERNANDEZ, Julio, POVEDANO PANADES, Mónica, ALBERTÍ AGUILO, Maria a., BELLA, Eleonora dalla, LAURIA, Giuseppe, PINTO, Wladimir b.v.r., DE SOUZA, Paulo v.s., OLIVEIRA, Acary s.b., TORO, Camilo, VAN IERSEL, Joost, PARSON, Malu, HARSCHNITZ, Oliver, VAN DEN BERG, Leonard h., VELDINK, Jan h., AL-CHALABI, Ammar, LEIGH, Peter n., VAN ES, Michael a.. Facial Onset Sensory and Motor Neuronopathy. _Neurology: Clinical Practice_. 2020. Vol. 11, núm. 2, pàgs. 147-157. [consulta: 23 de gener de 2026]. ISSN: 2163-0933. [Disponible a: https://hdl.handle.net/2445/178994]