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elife-93666-v1.pdf (2.69 MB)

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2024-02-14

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cc by (c) Diz de Almeida, Silvia et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222851

Novel risk loci for COVID-19 hospitalization among admixed American populations

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https://doi.org/10.7554/eLife.93666

Resum

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

Matèries

Polimorfisme genètic, COVID-19

Matèries (anglès)

Genetic polymorphisms, COVID-19

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

DIZ DE ALMEIDA, Silvia, PUJOL ONOFRE, Aurora and SCOURGE Cohort Group. Novel risk loci for COVID-19 hospitalization among admixed American populations. eLife. 2024. Vol. 13. ISSN 2050-084X. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/222851

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