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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/114190
Respiratory microbiota and lower respiratory tract disease
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INTRODUCTION: The respiratory airways harbor a complex
succession of ecological niches with distinct but related
bacterial communities. Particular challenges of respiratory
microbiome research have led to limited scientific output
compared to other human microbiomes. Areas covered: In this
review, we summarize the current state of knowledge of the
bacterial respiratory microbiome, with a particular focus on
associations between the respiratory microbiome and lower
respiratory tract conditions. Expert commentary: There is
growing evidence that the respiratory microbiome is associated
with lower respiratory infectious diseases and related
conditions. Most respiratory microbiome reports are
metataxonomic cross-sectional or case-control studies with
relatively small sample sizes. Large, prospective projects with
metatranscriptomics or metabolomics approach are needed to
unravel the effect of the respiratory microbiome on
health-related conditions. Moreover, standardization in
sampling, library preparation, sequencing techniques and data
analysis should be encouraged.
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LANASPA, Miguel, et al. Respiratory microbiota and lower respiratory tract disease. Expert Review of Anti-Infective Therapy. 2017. Vol. 15, num. 7, pags. 703-711. ISSN 1478-7210. [consulted: 8 of October of 2026]. Available at: https://hdl.handle.net/2445/114190