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2011-06-11

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cc by nc nd (c) Formiga Pérez, Francesc et al, 2011
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178415

Health and economic impact of the correct diagnosis of transthyretin cardiac amyloidosis in Spain

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https://doi.org/10.1080/14737167.2021.1933948

Resum

Objective: to estimate the health and economic impact of the reduction in mortality and cardiovascular hospitalizations, associated with correct diagnosis of cardiac transthyretin amyloidosis (ATTR-CM), from the Spanish National Health System (NHS) perspective. Methods: a costs and effects analysis were performed (probabilistic Markov model) with time horizons between 1 and 15 years, comparing the correct diagnosis of ATTR-CM versus the non-diagnosis. Transition probabilities were obtained from the ATTR-ACT study (placebo arm) and from the literature. Costs and healthcare resources were obtained from Spanish sources ( 2019) and from a panel of Spanish clinical experts. Results: after 1, 5, 10 and 15 years, the diagnosis of ATTR-CM would generate a gain of 0.031 (95%CI 0.025; 0.038); 0.387 (95%CI 0.329; 0.435); 0.754 (95%CI 0.678; 0.781) and 0.944 (95%CI 0.905; 0.983) life years per patient, respectively, with savings of 212 (95%CI -632; 633), 2,289 (95%CI 2,250; 2,517), 2,859 (95%CI 2,584; 3,149) and 2,906 (95%CI 2,669; 3,450) per patient, respectively, versus the non-diagnosis. Conclusions: just by correctly diagnosing ATTR-CM, years of life would be gained, cardiovascular hospitalizations would be avoided, and savings would be generated for the NHS, compared to the non-diagnosis of the disease.

Matèries

Amiloïdosi, Diagnòstic, Espanya

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Amyloidosis, Diagnosis, Spain

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

FORMIGA PÉREZ, Francesc, GARCIA PAVIA, Pablo, MARTÍN SÁNCHEZ, Francisco javier, NAVARRO-RUIZ, Andrés, RUBIO-TERRÉS, Carlos, PERAL, Carmen, TARILONTE, Patricia, LÓPEZ-IBÁÑEZ DE ALDECOA, Alejandra, RUBIO-RODRÍGUEZ, Darío. Health and economic impact of the correct diagnosis of transthyretin cardiac amyloidosis in Spain. _Expert Review of Pharmacoeconomics & Outcomes Research_. 2011. Vol. 11, núm. 1-7. [consulta: 24 de gener de 2026]. ISSN: 1473-7167. [Disponible a: https://hdl.handle.net/2445/178415]

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