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2023_56_Pineiro_ECP_rata.pdf (3.16 MB)

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2023-01-12

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cc-by (c) Piñeiro, Gastón Julio et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224373

Extracorporeal Photopheresis Improves Graft Survival in a Full-Mismatch Rat Model of Kidney Transplantation

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https://doi.org/10.3389/ti.2023.10840

Resum

Extracorporeal photopheresis (ECP) is an immunomodulatory therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV) in the presence of a photosensitizer. The study evaluates the ECP efficacy as induction therapy in a full-mismatch kidney transplant rat model. Dark Agouti to Lewis (DA-L) kidney transplant model has been established. ECP product was obtained from Lewis rat recipients after DA kidney graft transplantation (LewDA). Leukocytes of those LewDA rats were exposed to 8-methoxy psoralen, and illuminated with UV-A. The ECP doses assessed were 10 × 106 and 100 × 106 cells/time point. Lewis recipients received seven ECP infusions. DA-L model was characterized by the appearance of donor-specific antibodies (DSA) and kidney function deterioration from day three after kidney transplant. The dysfunction progressed rapidly until graft loss (6.1 ± 0.5 days). Tacrolimus at 0.25 mg/kg prolonged rat survival until 11.4 ± 0.7 days (p = 0.0004). In this context, the application of leukocytes from LewDA sensitized rats accelerated the rejection (8.7 ± 0.45, p = 0.0012), whereas ECP product at high dose extended kidney graft survival until 26.3 ± 7.3 days, reducing class I and II DSA in surviving rats. ECP treatment increases kidney graft survival in full-mismatch rat model of acute rejection and is a suitable immunomodulatory therapy to be explored in kidney transplantation.Copyright © 2023 Piñeiro, Lazo-Rodriguez, Ventura-Aguiar, Ramirez-Bajo, Banon-Maneus, Lozano, Cid, Hierro-Garcia, Cucchiari, Revuelta, Montagud-Marrahi, Palou, Bayés-Genís, Campistol, Diekmann and Rovira.

Matèries

Immunologia de la trasplantació, Trasplantament renal

Matèries (anglès)

Transplantation immunology, Kidney transplantation

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PIÑEIRO, Gastón julio, LAZO RODRÍGUEZ, Marta, VENTURA ABREU AGUIARÀ, Pedro, RAMÍREZ BAJO, María josé, BAÑÓN MANEUS, Elisenda, LOZANO MOLERO, Miguel, CID VIDAL, Joan, HIERRO GARCÍA, Natalia, CUCCHIARI, David, REVUELTA VICENTE, Ignacio, MONTAGUD MARRAHI, Enrique, PALOU RIBERA, Eduard, BAYÉS GENÍS, Beatriz enriqueta, CAMPISTOL PLANA, Josep m., DIEKMANN, Fritz, ROVIRA JUÁREZ, Jordi. Extracorporeal Photopheresis Improves Graft Survival in a Full-Mismatch Rat Model of Kidney Transplantation. _Transplant International_. 2023. Vol. 36, núm. 10840. [consulta: 8 de gener de 2026]. ISSN: 1432-2277. [Disponible a: https://hdl.handle.net/2445/224373]

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