Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker

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dc.contributor.authorTerra, Ximena
dc.contributor.authorCeperuelo Mallafré, Victoria
dc.contributor.authorMerma, Carla
dc.contributor.authorBenaiges, Ester
dc.contributor.authorBosch, Ramon
dc.contributor.authorCastillo, Paola
dc.contributor.authorFlores, Joan Carles
dc.contributor.authorLeon, Xavier
dc.contributor.authorValduvieco, Izaskun
dc.contributor.authorBaste, Neus
dc.contributor.authorCamara, Marina
dc.contributor.authorLejeune, Marylene
dc.contributor.authorGuma, Josep
dc.contributor.authorVendrell, Joan
dc.contributor.authorVilaseca, Isabel
dc.contributor.authorFernandez Veledo, Sonia
dc.contributor.authorAvilés Jurado, Francesc Xavier
dc.date.accessioned2022-03-04T19:12:16Z
dc.date.available2022-03-04T19:12:16Z
dc.date.issued2021-04-01
dc.date.updated2022-03-04T19:11:56Z
dc.description.abstractSimple Summary: Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous cell carcinoma (HNSCC) is associated with disease and treatmentrelated morbidity so there is an urgent need for innovation in treatment and diagnosis practices. Our aim was to evaluate the potential of the succinate-related pathway as a diagnostic and prognostic biomarker in HNSCC. The circulating succinate levels are increased in HNSCC, being a potential noninvasive biomarker for HNSCC diagnosis. Moreover, the succinate receptor (SUCNR1) and genes related to succinate metabolism, which are predominantly expressed in the tumoral mucosa as compared with healthy tissue, are positively associated with plasma succinate. Remarkably, we found that SUCNR1 and SDHA expression levels predict prognosis.
dc.format.extent16 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec713992
dc.identifier.issn2072-6694
dc.identifier.pmid33916314
dc.identifier.urihttps://hdl.handle.net/2445/183808
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cancers13071653
dc.relation.ispartofCancers, 2021, vol 13, num 7, p. 1-16
dc.relation.urihttps://doi.org/10.3390/cancers13071653
dc.rightscc-by (c) Terra, Ximena et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
dc.subject.classificationCàncer de cap
dc.subject.classificationCàncer de coll
dc.subject.otherHead cancer
dc.subject.otherNeck cancer
dc.titleSuccinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)