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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/43602
Factors Associated to Duration of Hepatitis A Outbreaks: Implications for Control
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Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 105 persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.
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TORNER GRÀCIA, Núria, BRONER, Sonia judith, MARTÍNEZ, Ana, TORTAJADA, Cecilia, GARCÍA DE OLALLA, Patricia, BARRABEIG I FABREGAT, Irene, SALA FARRÉ, Maria rosa, CAMPS, Neus, MINGUELL, Sofia, ALVAREZ, Josep, FERRÚS, Gloria, TORRA, Roser, GODOY I GARCÍA, Pere, DOMÍNGUEZ GARCÍA, Àngela, Hepatitis A Surveillance Group of Catalonia. Factors Associated to Duration of Hepatitis A Outbreaks: Implications for Control. _PLoS One_. 2012. Vol. 7, núm. 2, pàgs. e31339. [consulta: 30 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/43602]