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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/197680
Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics
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Synaptic activity is the main energy-consuming process in the central nervous system. We are beginning to understand how energy is supplied and used during synaptic activity by neurons. However, the long-term metabolic adaptations associated with a previous episode of synaptic activity are not well understood. Herein, we show that an episode of synaptic activity increases mitochondrial bioenergetics beyond the duration of the synaptic activity by transcriptionally inducing the expression of iron metabolism genes with the consequent enhancement of cellular and mitochondrial iron uptake. Iron is a necessary component of the electron transport chain complexes, and its chelation or knockdown of mitochondrial iron transporter Mfrn1 blocks the activity-mediated bioenergetics boost. We found that Mfrn1 expression is regulated by the well-known regulator of synaptic plasticity CREB, suggesting the coordinated expression of synaptic plasticity programs with those required to meet the associated increase in energetic demands.
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TENA-MORRAJA, Paula, RIQUÉ PUJOL, Guillem, MÜLLER SÁNCHEZ, Claudia alejandra, REINA DEL POZO, Manuel, CRUZ MARTÍNEZ, Ofelia, SORIANO ZARAGOZA, Francesc x. (francesc xavier). Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics. _International Journal of Molecular Sciences_. 2023. Vol. 24, núm. 2, pàgs. 1-14. [consulta: 23 de gener de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/197680]