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01 2011_PMID_20884709_Emergence of oligo.pdf (187.06 KB)

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2011-01-01

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cc-by (c) Ferrata Storti Foundation, 2011
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226240

Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents

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Recurs relacionat

https://doi.org/10.3324/haematol.2010.030882

Resum

The emergence of oligoclonal bands is associated with a favorable outcome after autologous stem cell transplantation in multiple myeloma. The aim of this study was to determine the prevalence of immunoglobulin oligoclonality in 33 patients with multiple myeloma in complete remission achieved with primary therapy with either cytotoxic agents (n = 18, 54.5%) or new induction regimens incorporating novel drugs (n = 15, 45.4%). Eleven patients (33.3%) developed oligoclonal bands. In the group treated with novel agents, this oligoclonal immune response was observed in 60% (9 of 15) of the patients versus only 11.1% (2 of 18) of those given cytotoxic therapy (P = 0.003). This is the first report showing a different frequency of oligoclonal humoral response in patients in complete remission achieved after conventional cytotoxic therapy versus induction incorporating novel agents. This difference could be due to a higher antitumor effect associated with the use of novel drugs, a stronger immune reconstitution, or both.

Matèries

Quimioteràpia del càncer, Tumors, Micologia mèdica

Matèries (anglès)

Cancer chemotherapy, Tumors, Medical mycology

Citació

Col·leccions

Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

FERNÁNDEZ DE LARREA RODRÍGUEZ, Carlos José, et al. Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents. Haematologica. 2011. Vol. 96, num. 1, pags. 171-173. ISSN 1592-8721. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/226240

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